Abstract Background Ischemic cardiomyopathy and resultant heart failure (HF) is a significant cause of morbidity and mortality worldwide.Downregulation of cardiac bridging integrator 1 (cBIN1), a membrane scaffolding protein responsible for organizing t-tubules and organizing the calcium handing apparatus, occurs in progressive HF.Therefore, gene t

IntroductionPostoperative cognitive decline (PCD) can affect in excess of 10% of surgical patients and can be considerably higher with risk factors including advanced age, perioperative infection, and metabolic conditions such as obesity and insulin resistance.To define underlying pathophysiologic processes, we used animal models including a rat mo

The article discusses classifications of medicines for Antioxidants gene and cell therapy.Data on medicinal products registered in Russia, as well as in the European Union countries, Great Britain, USA, and Japan is presented.The limitations on using such medicinal products were considered, including their high utilitarian cost and high risk of adv